Cigarette smoke induces MUC5AC expression through the activation of Sp1
نویسندگان
چکیده
Background: Cigarette smokers have increased mucus secretion and MUC5AC gene expression. Results: Cigarette smoke increases Sp1 protein expression and activates Sp1 binding to a smoke responsive promoter region of the MUC5AC. Conclusion: Sp1 is the key regulator of cigarette smoke-induced MUC5AC mRNA transcription in lung epithelial cells. Significance: Sp1 may be a putative target to treat mucus hypersecretion in COPD patients.
منابع مشابه
Caveolin-1 aggravates cigarette smoke extract-induced MUC5AC secretion in human airway epithelial cells.
Airway mucus hypersecretion is a major pathological characteristic of chronic obstructive pulmonary disease (COPD), and cigarette smoke is highly implicated in mucus secretion and the development of COPD. Cigarette smoke reportedly induces mucin overproduction through the epidermal growth factor receptor (EGFR) in the airway epithelium; however, the underlying mechanisms responsible for the act...
متن کاملRegulation of cigarette smoke-mediated mucin expression by hypoxia-inducible factor-1α via epidermal growth factor receptor-mediated signaling pathways.
Cigarette smoking is strongly implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). Mucus hypersecretion is the key manifestation in patients with COPD and mucin 5AC (MUC5AC) is a major component of airway mucus. Hypoxia inducible factor-1 (HIF-1) is a transcriptional factor which can be stimulated to bind to the MUC5AC promoter and induce MUC5AC promoter activation. P...
متن کاملActivation of epidermal growth factor receptors is responsible for mucin synthesis induced by cigarette smoke.
Mucus hypersecretion from hyperplastic airway goblet cells is a hallmark of chronic obstructive pulmonary disease (COPD). Although cigarette smoking is thought to be involved in mucus hypersecretion in COPD, the mechanism by which cigarette smoke induces mucus overproduction is unknown. Here we show that activation of epidermal growth factor receptors (EGFR) is responsible for mucin production ...
متن کاملHyaluronan fragments/CD44 mediate oxidative stress-induced MUC5B up-regulation in airway epithelium.
Mucus hypersecretion with elevated MUC5B mucin production is a pathologic feature in many airway diseases associated with oxidative stress. In the present work, we evaluated MUC5B expression in airways and in primary cultures of normal human bronchial epithelial (NHBE) cells, as well as the mechanisms involved in its regulation. We found that oxidative stress generated by cigarette smoke or rea...
متن کاملA role for 12R-lipoxygenase in MUC5AC expression by respiratory epithelial cells.
Eicosanoids are metabolites of arachidonic acid produced by cyclooxygenases (COXs) or lipoxygenases (LOXs). They mediate inflammation and mucus secretion in chronic pulmonary inflammatory diseases. The gel-forming mucin MUC5AC is over-expressed in the airways of patients with these diseases. MUC5AC expression is mediated by an extracellular signal-regulated kinase (ERK)/Sp1 dependent mechanism....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2012